Morphologic effects of hypervitaminosis a on rat submandibular gland

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Morphologic effects of hypervitaminosis A on rat submandibular gland.

Young male Sprague-Dawley rats were fed oral supplements of vitamin A; either a subtoxic dose of 5000 i.u./day for 16 weeks (10 animals), or a toxic dose of 15,OOOi.u./day for 16 days (5 animals). High-dose animals exhibited signs of acute toxicity; low-dose animals demonstrated only less weight gain than controls. Vitamin A sera and liver levels evidenced intoxication. Light and electron micro...

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the effect of acute hypervitaminosis a on submandibular glands function

pure submandibular saliva was collected from anaesthetized vitamin - a - treated and control rats with using of pilocarpine as secretogogue, and then the serum was collected by cardiac puncutre. intraperitoneal injection of a large single dose (100,000 iu/kg) of vitamin a changed total protein, calcium and sodium concentrations of saliva so that sodium level of submandibular saliva was reduced ...

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ژورنال

عنوان ژورنال: Archives of Oral Biology

سال: 1972

ISSN: 0003-9969

DOI: 10.1016/0003-9969(72)90047-7